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M94A3328.TXT
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1994-10-25
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Document 3328
DOCN M94A3328
TI Possible role of HIV gp120 in CD2/LFA-3 activation pathway.
DT 9412
AU Blinov VM; Resenchuk SM; Denisov SI; Chirikova GB; Zverev VV; Institute
of Molecular Biology, Koltsovo, Novosibirsk, Russia.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):100 (abstract no. PA0019). Unique
Identifier : AIDSLINE ICA10/94369247
AB The CD2 molecule belongs to a family of cell-surface glycoproteins that
function as adhesion molecules in the immune system. Human CD2 is found
exclusively on cells of the T lineage: peripheral T lymphocytes, NK
cells, and thymocytes. CD2 binds specifically to the surface
glycoprotein LFA-3. More importantly, CD2/LFA-3 adhesion functions in
the immune system to augment T cell activation; it initiates conjugate
formation between participating T cells and antigen-presenting cells.
Molecular mimicry between T-cell receptors and viral HIV proteins has
been suggested as a possible cause of initiation or continuation of the
autoimmune reaction in HIV infection. Search for the possible homologies
between the HIV proteins within cellular protein sequences database
revealed high similarity level with the LFA-3. The region of homology
with LFA-3 proved to be the amino-terminal portion of gp 120, which may
be a part of the site for interaction with cellular receptor CD2. The
deduced amino acid sequence of the immunoglobulin-like domain in
NH2-terminal of gp 120 reveals the conservation of typical features of
immunoglobulin-like domain in the proteins of immunoglobulin
superfamily.
DE Antigens, CD/GENETICS/*PHYSIOLOGY Antigens, Differentiation,
T-Lymphocyte/*PHYSIOLOGY Binding Sites/GENETICS Cell Adhesion
Molecules/GENETICS/PHYSIOLOGY Conserved Sequence Human HIV Envelope
Protein gp120/GENETICS/*PHYSIOLOGY HIV
Infections/IMMUNOLOGY/MICROBIOLOGY HIV-1/GENETICS/*PHYSIOLOGY Membrane
Glycoproteins/GENETICS/*PHYSIOLOGY Receptors, Immunologic/*PHYSIOLOGY
Sequence Homology, Amino Acid T-Lymphocytes/IMMUNOLOGY/MICROBIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).